A pharmacological and toxicological profile of silver as an antimicrobial agent in medical devices. It is believed that silver attains a brownish-black tone through a chemical reduction reaction or through a photomediated exacerbation of its stimulatory effect on melanine synthesis. The reason why the grey color is more evident on photoexposed skin areas is unknown. Skin pigmentation is caused not only by silver deposition (in sulfite or selenite forms) in the dermis but also, according to some authors, by the stimulation of melanine synthesis. Argyria: permanent skin discoloration following protracted colloid silver ingestion. Scar-localized Argyria secondary to silver sulfadiazine cream. A Case of Argyria following colloidal silver ingestion.
Kwon H, Lee J, Lee S, Lee A, Choi J, Ahn Y. Rapid onset of Argyria induced by a silver-containing dietary supplement.
Bowden L, Rover M, Hallman J, Lewin-Smith M, Lupton G. Several different types of exposure (accidental, therapeutic, occupational and environmental), routes of administration (oral, intranasal and percutaneous) and intervals of exposure from 8 months to 5 years have been described. The amount of absorbed silver required to cause generalized Argyria pigmentation is unknown. Its current routine use as mainly an antibacterial and antifungal agent in chronic wound care products, medical devices and certain textiles, calls for a reappraisal of one of its potential side effects.Īrgyria is a rare disease caused by the chronic absorption of products with a high silver content which surpass the body's renal and hepatic excretory capacities, leading to silver granules being deposited in the skin and its appendages, mucosae and internal organs (including the eye, kidney, spleen, bone marrow and central nervous system), and causing them to acquire a blue-grey pigmentation. The medicinal use of silver dates back to the beginning of medical history.
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